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Other drugs that were tried in some patients in the present report are baclofen, creatine, coenzyme-Q10, donepezil, gabapentin, galantamine, nicotine (patch), pramipexole, valproic acid, yohimbine and zolpidem.

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The authors say: "These results suggest that specific stimulation of dopaminergic pathways as provided by pramipexole should be considered in the management of patients with PD and clinically-significant depressive symptoms.

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Dopaminergic drugs (drugs that increase levels of dopamine) are the standard medicines for treating severe RLS, PLMD, or both.

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